Auditory filter width affects response magnitude but not frequency specificity in auditory cortex.

نویسندگان

  • Björn Herrmann
  • Molly J Henry
  • Mathias Scharinger
  • Jonas Obleser
چکیده

Spectral analysis of acoustic stimuli occurs in the auditory periphery (termed frequency selectivity) as well as at the level of auditory cortex (termed frequency specificity). Frequency selectivity is commonly investigated using an auditory filter model, while frequency specificity is often investigated as neural adaptation of the N1 response in electroencephalography (EEG). However, the effects of aging on frequency-specific adaptation, and the link between peripheral frequency selectivity and neural frequency specificity have not received much attention. Here, normal hearing younger (20-31 years) and older participants (49-63 years) underwent a psychophysical notched noise experiment to estimate individual auditory filters, and an EEG experiment to investigate frequency-specific adaptation in auditory cortex. The shape of auditory filters was comparable between age groups, and thus shows intact frequency selectivity in normal aging. In auditory cortex, both groups showed N1 frequency-specific neural adaptation effects that similarly varied with the spectral variance in the stimulation, while N1 responses were overall larger for older than younger participants. Importantly, the overall N1 amplitude, but not frequency-specific neural adaptation was correlated with the pass-band of the auditory filter. Thus, the current findings show a dissociation of peripheral frequency selectivity and neural frequency specificity, but suggest that widened auditory filters are compensated for by a response gain in frequency-specific areas of auditory cortex.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bidirectional Regulation of Innate and Learned Behaviors That Rely on Frequency Discrimination by Cortical Inhibitory Neurons.

The ability to discriminate tones of different frequencies is fundamentally important for everyday hearing. While neurons in the primary auditory cortex (AC) respond differentially to tones of different frequencies, whether and how AC regulates auditory behaviors that rely on frequency discrimination remains poorly understood. Here, we find that the level of activity of inhibitory neurons in AC...

متن کامل

Fine frequency tuning in monkey auditory cortex and thalamus.

The frequency resolution of neurons throughout the ascending auditory pathway is important for understanding how sounds are processed. In many animal studies, the frequency tuning widths are about 1/5th octave wide in auditory nerve fibers and much wider in auditory cortex neurons. Psychophysical studies show that humans are capable of discriminating far finer frequency differences. A recent st...

متن کامل

Functional MRI of human auditory cortex using block and event-related designs.

fMRI of human auditory cortex response to sinusoidal tones of 200, 1000, and 3000 Hz was evaluated using block design and conventional and "silent" event-related designs. Conventional event-related fMRI revealed the timecourse of the BOLD response (approximately 5 sec to peak, approximately 4 sec full-width-half-max, and approximately 14 sec recovery to baseline). Both event-related, but not bl...

متن کامل

Title: Fine Frequency Tuning in Monkey Auditory Cortex and Thalamus

23 The frequency resolution of auditory neurons throughout the ascending auditory pathway 24 is an important parameter for understanding how sounds are processed. It has been shown in 25 previous animal studies that the frequency tuning widths are about 1/5 octave wide in auditory 26 nerve fibers and much wider in auditory cortex neurons (Pickles, 1979; McLaughlin et al., 2008; 27 see Table 1)....

متن کامل

Evidence for modality-specific but not frequency-specific modulation of human primary auditory cortex by attention.

We used the stimulus-driven 40-Hz auditory steady-state response (ASSR) that localizes tonotopically to the region of primary auditory cortex (A1) to study modulation of this region by top-down attention. Experiment 1 presented amplitude modulated (AM) auditory and visual stimuli simultaneously (AM at 40 Hz and 16 Hz, respectively) while participants responded to targets in one modality or the ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Hearing research

دوره 304  شماره 

صفحات  -

تاریخ انتشار 2013